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Dysregulated immune response in SARS-CoV-2 infections


 Department of Anesthesiology and Intensive Care, Faculty of Medicine, Udayana University, Bali, Indonesia

Correspondence Address:
Marilaeta Cindryani,
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Udayana University, Bali
Indonesia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/BJOA.BJOA_116_20

Coronaviruses have caused several global challenges for health-care providers all over the world. The notorious SARS-CoV-2 could attack the lower respiratory tract and trigger the immune systems to release massive number of immune cells and pro-inflammatory cytokines and cause immunopathology consequences called cytokine release syndrome. These pro-inflammatory cytokines and other immune cells caused lung injury and severe acute respiratory distress syndrome in COVID-19 (CARDS) and multiple organ failure. There are still many intertwined immune responses that not yet been discovered in SARS-CoV-2 infections. Targeted and specific cell therapy would be reasonable and considered safer to be employed in patients who present with comorbidities and at risk of complications.


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