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REVIEW ARTICLE
Year : 2019  |  Volume : 3  |  Issue : 1  |  Page : 27-32

The role of endothelial glycocalyx in sepsis


1 Department of Pediatrics, Pain Management, and Intensive Care Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia
2 Department of Anesthesiology, Pain Management, and Intensive Care Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia

Correspondence Address:
I Nyoman Budi Hartawan
Department of Pediatrics Faculty of Medicine, Udayana University Jl. PB Sudirman, Denpasar 80232, Bali
Indonesia
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Source of Support: None, Conflict of Interest: None


DOI: 10.15562/bjoa.v3i1.114

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The surface of endothelial cells is filled with various membrane-bound molecules that form the glycocalyx. The endothelial glycocalyx is a surface layer mainly consisted of glycosaminoglycans that include heparan sulfate, chondroitin sulfate, and hyaluronic acid and its core proteins. Previous studies suggest that endothelial surface glycocalyx shedding could play a role in endothelial dysfunction and inflammation. This article will review the endothelial glycocalyx and its role in sepsis.


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