Header bg
  • Users Online: 198
  • Print this page
  • Email this page
Header bg
Year : 2019  |  Volume : 3  |  Issue : 1  |  Page : 1-4

Co-administration of dexmedetomidine and levobupivacaine results in better onset and duration of epidural anesthesia in lower extremity orthopedic surgery

1 Department of Anesthesiology and Intensive Care, Sriwijaya University, Palembang, Indonesia
2 Department of Pharmacology Faculty of Medicine, Sriwijaya University, Palembang, Indonesia

Correspondence Address:
Ihsan Affandi
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Sriwijaya University Jl. Jend. Sudirman KM. 3.5, Palembang, South Sumatera 30126
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.15562/bjoa.v3i1.61

Rights and Permissions

Background: The goal of this study is to know the efficacy of the addition of 0.5 mcg/kg dexmedetomidine to 15 mL isobaric 0.5% levobupivacaine on the onset and duration of sensory and motor blockade of epidural anesthesia in lower extremity orthopedic surgery. Methods: Randomized clinical double-blind trials were conducted in Dr. Mohammad Hoesin Hospital Palembang. A total of 34 patients underwent lower extremity surgery met the inclusion and exclusion criteria. Data were analyzed by independent t-test and Mann-Whitney test using SPSS 22.0 software. Result: The onset of sensory block in group D was 5.41±1.84 minutes compared to 17.59± 2.65 in Group C (p <0.001), as seen in [Table 2]. The sensory block duration was 362.41±25.66 minutes in Group D compared to 215.82±15.69 in Group C (p <0.001). The onset of the motoric block in group D was 16.53±1.81 minutes compared to 26.12±2.78 in Group C (p <0.001), while the motoric block duration was 301.29±20.55 minutes in Group D compared to 167.35±17.24 in Group C (p <0.001). Conclusion: The addition of 0.5mcg/kg dexmedetomidine to 15 ml isobaric 0.5% levobupivacaine in epidural anesthesia provide faster onset and prolonged duration in both motoric and sensory block in patients undergoing lower extremity surgery.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded46    
    Comments [Add]    

Recommend this journal